2-Nitrophenylacetonitrile, CAS No. 610-66-2

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610-66-2

Catalog No. EBD39497

CAS 610-66-2

Name 2-Nitrophenylacetonitrile

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Basic Information

Synonyms: 2-Nitrophenylacetonitrile 2-Nitrobenzylcyanide 2-nitrobenzeneacetonitrile O-nitrobenzylcyanide 2-nitrophenylaceticacid,nitrile O-nitrophenylacetonitrile

Molecular Formula: C8H6N2O2

Molecular Weight: 162.15

MDL Number: MFCD00007183

Categories: Synthetic Chemistry > Organic Building Blocks > Cyano Compounds Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

2-Nitrophenylacetonitrile is an organic compound featuring a benzene ring substituted with a nitrile group and a nitro group at the ortho position. It is a pale yellow to yellow crystalline solid with a molecular formula of C8H6N2O2. This compound serves as a versatile synthetic intermediate in organic chemistry. Its primary application is in the synthesis of indole derivatives, a crucial scaffold in medicinal chemistry. The nitrile and nitro groups are reactive handles that can be transformed into various functional groups, such as amines, carboxylic acids, and heterocycles. It is notably used in the synthesis of important pharmaceutical intermediates, including precursors to tryptamine and other bioactive molecules containing the indole nucleus. As a building block, it is valued for its role in constructing complex nitrogen-containing heterocycles. Standard safety precautions for handling nitriles and nitroaromatic compounds should be observed, including the use of personal protective equipment due to potential toxicity.

Physical Properties

Melting Point: 82-85 °C(lit.)

Boiling Point: 178°C

Flash Point: 138 °C

Density: 1.272 g/cm3

Solubility: <0.01 g/100 mL at 20 ºC