6β-Hydroxy-tropinon, CAS No. 5932-53-6

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5932-53-6

Catalog No. EBD2224522

CAS 5932-53-6

Name 6β-Hydroxy-tropinon

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Basic Information

Synonyms: Scopin 6β-Hydroxy-tropinon (±)-exo-6-Hydroxytropinone (+/-)-exo-6-Hydroxytropinone exo-6-Hydroxytropinone 6-Hydroxy-8-methyl-8-azabiscyclo[3.2.1]octan-3-one 6-Hydroxytropinone 6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-one (1S,5S,6R)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-one (1S,5S,6S)-6-hydroxy-8-methyl-3-oxo-8-azoniabicyclo[3.2.1]octane 6-hydroxy?tropinone

Molecular Formula: C8H13NO2

Molecular Weight: 155.2

MDL Number: MFCD00005550

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

Product Description:

6-Hydroxytropinone is a bicyclic alkaloid derivative, specifically a tropane alkaloid. It is a key intermediate in the chemical synthesis of scopolamine (hyoscine), a muscarinic antagonist with significant therapeutic applications. Its primary industrial and research significance lies in its role as a crucial synthetic precursor. The compound serves as a pivotal building block in multi-step synthetic routes to produce scopolamine, a valuable active pharmaceutical ingredient (API). Scopolamine is widely used in the treatment of motion sickness, postoperative nausea and vomiting, and as a pre-anesthetic medication. Due to its structural complexity and specific reactivity, 6-hydroxytropinone is not considered a general-purpose organic synthesis building block. Its production and use are almost exclusively tied to the pharmaceutical synthesis of scopolamine and related tropane alkaloid derivatives.

Physical Properties

Melting Point: 120-121 °C(lit.)

Boiling Point: 291.6 °C at 760 mmHg

Flash Point: 130.1 °C

Density: 1.217 g/cm3

Analytical Data

Appearance: White powder.