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    590418-08-9

    Catalog No. EBD46184

    CAS 590418-08-9

    Name (1-Methyl-1H-indazol-5-yl)boronic acid

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    Basic Information

    Synonyms: (1-methyl-1H-indazol-5-yl)boronicacid 1-methyl-1H-indazol-5-ylboronicacid Boronicacid,B-(1-methyl-1H-indazol-5-yl)- 1-Methylindazol-5-boronicacid

    Molecular Formula: C8H9BN2O2

    Molecular Weight: 175.98

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters

    Product Description:
    1-Methyl-1H-indazole-5-boronic acid is a heterocyclic boronic acid derivative featuring an indazole core substituted with a methyl group at the N1 position and a boronic acid functional group at the 5-position. Boronic acids are pivotal reagents in modern synthetic chemistry, particularly in Suzuki-Miyaura cross-coupling reactions, which are widely employed for the construction of carbon-carbon bonds. Its primary application is as a key pharmaceutical intermediate or building block in medicinal chemistry research and drug discovery. The indazole scaffold is a privileged structure found in numerous bioactive molecules and drug candidates targeting various therapeutic areas, including oncology and central nervous system disorders. The boronic acid group allows for efficient incorporation of this heterocyclic unit into more complex molecular architectures via palladium-catalyzed coupling, facilitating the rapid synthesis of compound libraries for biological screening. As a specialized boronic acid building block, it is not considered a commodity chemical but is valuable for constructing molecules with potential pharmacological activity. Standard safety precautions for handling boronic acids and laboratory chemicals should be observed.
    Physical Properties

    Boiling Point: 397.472°C at 760 mmHg

    Flash Point: 194.184°C

    Density: 1.271g/cm3

    mg g kg ml l t