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    590417-56-4

    Catalog No. EBD1393086

    CAS 590417-56-4

    Name (1-Methyl-1H-indol-4-yl)boronic acid

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    Basic Information

    Synonyms: 1-Methyl-1H-indole-4-boronicacid B-(1-Methyl-1H-indol-4-yl)boronicacid (1-Methyl-1H-indol-4-yl)boronicacid

    Molecular Formula: C9H10BNO2

    Molecular Weight: 174.99

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters

    Product Description:
    B-(1-Methyl-1H-indol-4-yl)boronic acid is an organoboron compound featuring a boronic acid functional group attached to a 1-methylindole scaffold. This structure makes it a valuable heterocyclic building block in synthetic chemistry, particularly in Suzuki-Miyaura cross-coupling reactions, which are pivotal for constructing biaryl and heterobiaryl systems. Its primary application is in pharmaceutical research and development as a key intermediate. The indole moiety is a privileged structure in medicinal chemistry, found in numerous bioactive molecules. This specific boronic acid derivative is utilized in the synthesis of complex drug candidates, especially those targeting various therapeutic areas where the indole core is pharmacologically relevant. It serves as a crucial coupling partner to introduce the 1-methylindol-4-yl fragment into target molecules. As a specialized boronic acid, it requires careful handling under inert conditions (e.g., nitrogen or argon) to prevent protodeboronation and maintain stability. It is typically stored at low temperatures (e.g., 2-8°C or -20°C) to preserve its reactivity for use in palladium-catalyzed cross-coupling protocols.
    Physical Properties

    Boiling Point: 402.6 °C at 760 mmHg

    Flash Point: 1.16 g/cm3

    Density: 1.16 g/cm3

    mg g kg ml l t