Indolin-2-one, CAS No. 59-48-3

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59-48-3

Catalog No. EBD53114

CAS 59-48-3

Name Indolin-2-one

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Basic Information

Synonyms: 2,3-dihydroindol-2-one 1,3-dihydro-2H-indol-2-one O-(Aminophenyl)AceticacidLactam TIMTEC-BBSBB004215 2-Oxindole 2-indolinone Oxindole Indolin-2-one

Molecular Formula: C8H7NO

Molecular Weight: 133.15

MDL Number: MFCD00005711

Categories: Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Other Organic Building Blocks

Product Description:

Indolin-2-one is a bicyclic heterocyclic compound featuring a fused benzene ring with a five-membered lactam ring. It serves as a core scaffold in medicinal chemistry, particularly for synthesizing indole-based pharmaceuticals. This compound is a key intermediate in the production of various central nervous system (CNS) drugs, including antidepressants and antipsychotics. It acts as a precursor for molecules targeting serotonin and dopamine receptors, such as the antipsychotic agent ziprasidone. Additionally, it is utilized in the synthesis of kinase inhibitors and other bioactive molecules. Indolin-2-one is a stable solid at room temperature and is commonly employed in research and industrial settings for drug discovery and development. Its structural versatility allows for functionalization at multiple positions, making it a valuable building block in organic synthesis.

Physical Properties

Melting Point: 123-128 °C(lit.)

Boiling Point: 227 °C/73 mmHg(lit.)

Flash Point: 194-196°C/17mm

Density: 1.198 g/cm3

Solubility: insoluble

Analytical Data

Appearance: beige to yellowish-orange or pinkish-brown powder