tert-butyl3-hydroxypropylcarbamate, CAS No. 58885-58-8

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58885-58-8

Catalog No. EBD47309

CAS 58885-58-8

Name tert-butyl3-hydroxypropylcarbamate

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Basic Information

Synonyms: boc-nh-(ch2)3-oh 3-(boc-amino)propanol boc-3-amino-1-propanol 3-(n-boc-amino)propanol n-t-butoxycarbonyl-beta-alaninol 3-(t-butoxycarbonylamino)-1-propanol n-t-butoxycarbonyl-3-amino-1-propanol tert-butyl(3-hydroxypropyl)carbamate tert-butyln-(3hydeoxypropyl)carbamate 3-(tert-butoxycarbonylamino)-1-propanol tert-butyln-(3-hydroxypropyl)carbamate n-t-butyloxycarbonyl-3-hydroxy-propylamine N-(3-Hydroxypropyl)carbamicacidtert-butylester 3-(boc-amino)-1-propanol tert-butyl3-hydroxypropylcarbamate boc-nh-pr-oh boc-beta-ala-ol

Molecular Formula: C8H17NO3

Molecular Weight: 175.23

MDL Number: MFCD00191883

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

3-(tert-Butoxycarbonylamino)-1-propanol is a bifunctional organic compound featuring both a primary alcohol group and a tert-butoxycarbonyl (Boc)-protected primary amine group. It serves as a versatile building block in organic synthesis, particularly in medicinal chemistry. Its primary application is as a key intermediate in the synthesis of various pharmaceutical compounds. The Boc-protected amine is a crucial handle for peptide coupling and the introduction of aminoalkyl side chains. It is notably used in the synthesis of biologically active molecules, including enzyme inhibitors and receptor ligands. The alcohol group can be further functionalized, making it a flexible linker for constructing more complex molecular architectures. This compound is a stable, crystalline solid under standard conditions. As with many Boc-protected amines, it requires careful handling in acidic environments, as the Boc group is acid-labile. It is a common reagent available from fine chemical suppliers for research and development purposes.

Physical Properties

Boiling Point: 292.6 °C at 760 mmHg

Flash Point: 109 °C

Density: 1.025 g/mL at 20 °C(lit.)

Refractivity: n20/D 1.453

Analytical Data

Appearance: colorless to yellow or brown liquid