17-hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione 17-acetate, CAS No. 58652-20-3

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58652-20-3

Catalog No. EBD32400

CAS 58652-20-3

Name 17-hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione 17-acetate

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Basic Information

Synonyms: NomegestroneAcetate Nomegestrol?17-acetate (17alpha)-17-acetyl-6-methyl-3-oxoestra-4,6-dien-17-ylacetate Nomegestrolacetate Normegestrolacetate 17-hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione17-acetate

Molecular Formula: C23H30O4

Molecular Weight: 370.49

Categories: Medicinal Chemistry > APIs and Their Salts > Endocrine & Metabolic Drugs Medicinal Chemistry > APIs and Their Salts > Other Drugs

Product Description:

Nomegestrol acetate, also known as 17-hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione 17-acetate, is a synthetic steroidal progestin. It is a derivative of 19-norprogesterone and is structurally characterized by the absence of the C-19 methyl group and the presence of a 4,6-diene-3-one system and a 17α-acetoxy group. Nomegestrol acetate is primarily used as an active pharmaceutical ingredient (API) in hormonal contraceptives and for the treatment of gynecological disorders such as endometriosis and dysfunctional uterine bleeding. It exhibits high progestogenic activity and strong anti-gonadotropic effects with minimal androgenic, estrogenic, or glucocorticoid activity. It is often combined with estradiol for use in oral contraceptives and hormone replacement therapy. This compound is a selective progesterone receptor agonist and is noted for its favorable metabolic profile, including a neutral or beneficial effect on lipid metabolism and minimal impact on body weight. It is not a common building block for general organic synthesis but is specifically manufactured as a high-purity drug substance for pharmaceutical formulations.

Physical Properties

Color: white to tan

Boiling Point: 507.3 °C at 760 mmHg

Flash Point: 219.8 °C

Density: 1.16 g/cm3

Storage: 2-8°C

Safety Information

Packing Level: III

Hazard Category: 9

Transport Codes: 3077