(S)-(-)-Anatabine is a pyridine alkaloid with the chemical name 3-[(2S)-1,2,3,6-tetrahydropyridin-2-yl]pyridine. It is a structural isomer of anabasine and is found naturally in plants of the Solanaceae family, including tobacco (*Nicotiana tabacum*) and eggplant (*Solanum melongena*). It is a chiral compound, with the (S)-enantiomer being the naturally occurring form. This alkaloid has garnered significant research interest in the pharmaceutical and nutraceutical fields. It is a minor tobacco alkaloid and a potential biomarker for tobacco use. More importantly, (S)-(-)-Anatabine exhibits notable biological activities, including anti-inflammatory properties. It has been investigated as a potential therapeutic agent for conditions like Alzheimer's disease and autoimmune disorders, acting through mechanisms that may involve the modulation of nicotinic acetylcholine receptors and the STAT3 signaling pathway. It is also available as a dietary supplement. As a chiral, bicyclic amine containing both a pyridine and a tetrahydropyridine ring, (S)-(-)-Anatabine serves as a valuable and complex synthetic building block in organic and medicinal chemistry for the construction of novel nitrogen-containing heterocycles and potential drug candidates.