quinolin-2-amine, CAS No. 580-22-3

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580-22-3

Catalog No. EBD2204601

CAS 580-22-3

Name quinolin-2-amine

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Basic Information

Synonyms: 2-Aminoquinoline Aminoquinoline Quinolin-2-amine 2-aminoquinolinium 2-quinolinamine

Molecular Formula: C9H8N2

Molecular Weight: 144.17

MDL Number: MFCD00038079

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

2-Aminoquinoline is an organic compound featuring a quinoline ring system substituted with an amino group at the 2-position. It is a solid with a molecular formula of C9H8N2 and serves as a versatile heterocyclic building block in organic synthesis. Its primary application is in the pharmaceutical industry as a key intermediate for the synthesis of various bioactive molecules. It is notably used in the preparation of antimalarial drugs, such as chloroquine and amodiaquine analogs, where the quinoline core is essential for activity. Furthermore, it finds use in the development of kinase inhibitors, antibacterial agents, and other therapeutic compounds targeting diverse biological pathways. Beyond medicinal chemistry, 2-aminoquinoline is employed as a ligand in coordination chemistry and catalysis, and as a precursor for the synthesis of functional dyes and fluorescent probes. It is also a common starting material in academic research for constructing more complex nitrogen-containing heterocycles.

Physical Properties

Melting Point: 126-131 °C

Boiling Point: 304.9 °C at 760 mmHg

Flash Point: 163.6 °C

Density: 6 g/cm3

Solubility: soluble

Analytical Data

Appearance: colorless to light yellow liquid