(R)-alpha-Methyl-4-nitrobenzylamine hydrochloride, CAS No. 57233-86-0

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57233-86-0

Catalog No. EBD47624

CAS 57233-86-0

Name (R)-alpha-Methyl-4-nitrobenzylamine hydrochloride

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Basic Information

Synonyms: (R)-ALPHA-METHYL-4-NITROBENZYLAMINEHYDROCHLORIDE (R)-(+)-ALPHA-METHYL-4-NITROBENZYLAMMONIUMCHLORIDE (R)-A-METHYL-4-NITROBENZYLAMINEHCL (R)-alpha-Methyl-4-nitrobenzylamineHCl (1R)-1-(4-nitrophenyl)ethanaminehydrochloride (1R)-1- (R)-(+)-A-methyl4-nitrobenzylaminehydrochloride (R)-1-(4-nitrophenyl)ethylaminehydro-chloride (R)-α-Methyl-4-nitrobenzylaminehydrochloride (R)-(-)-1-(4-NITROPHENYL)-ETHYLAMINEHCL (R)-1-(4-NITROPHENYL)ETHYLAMINEHYDROCHLORIDE (R)-4-NITROPHENYL-1-ETHYLAMINEHYDROCHLORIDE (R)-(-)-ALPHA-METHYL-4-NITROBENZYLAMINEHCL

Molecular Formula: C8H11ClN2O2

Molecular Weight: 202.64

MDL Number: MFCD00066311

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

(R)-alpha-Methyl-4-nitrobenzylamine hydrochloride is a chiral amine derivative, specifically the hydrochloride salt of (R)-1-(4-nitrophenyl)ethan-1-amine. It is characterized by a methyl group and a 4-nitrophenyl group attached to a chiral carbon center bearing the amine functionality. This compound is primarily employed as a key chiral building block or intermediate in pharmaceutical synthesis. The presence of the chiral center makes it valuable for constructing active pharmaceutical ingredients (APIs) where stereochemistry is crucial for biological activity. The nitro group serves as a versatile synthetic handle that can be readily reduced to an aniline, enabling further derivatization. Its main application lies in the research and development of enantiomerically pure drugs. As a chiral amine synthon, it is also relevant in asymmetric synthesis and as a precursor for ligands or resolving agents. It is typically handled as a solid and requires storage under appropriate conditions to maintain stability.

Physical Properties

Melting Point: 248-250 °C(lit.)

Boiling Point: 321.3 °C at 760 mmHg

Flash Point: 148.1 °C