Tricine, CAS No. 5704-04-1

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5704-04-1

Catalog No. EBD3472

CAS 5704-04-1

Name Tricine

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Basic Information

Synonyms: N-[Tris(hydroxymethyl)methyl]glycine TricineN-Tris(hydroxymethyl)methylglycine N-(Trishydroxymethylmethyl)glycine N-(tri(hydroxymethyl)methyl)glycine Tricine,MolecularBiologyGradeN-Tris(hydroxymethyl)methylglycine,MolecularBiologyGrade Tricine,ULTROLGrade N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycine LABOTEST-BBLT00454966 n-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-glycin TRI(HYDROXYMETHYL)AMINOMETHANEHYDROCHLORIDE TRIMETHYLOLAMINOMETHANEHYDROCHLORIDE TRIS-HCLBUFFER N-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]glycine N-(2-Hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine Tricine n-[2-hydroxy-1,1-bis(hydro

Molecular Formula: C6H13NO5

Molecular Weight: 179.17

MDL Number: MFCD00004277

Categories: Medicinal Chemistry > Pharmaceutical Excipients > Isotonic Agents, pH Adjusters, and Buffers Medicinal Chemistry > Biochemicals and Life Science Reagents > Other Biochemicals and Life Science Reagents

Product Description:

Tricine, chemically named N-[tris(hydroxymethyl)methyl]glycine, is a zwitterionic amino acid derivative and a member of the Good's buffers family. Its structure features a tertiary amine and three hydroxyl groups, providing high buffering capacity in the physiological pH range. Tricine is primarily used as a biological buffer in biochemical and molecular biology research, particularly for electrophoresis and protein crystallization. It is a key component in Tricine-SDS-PAGE systems for separating low molecular weight proteins and peptides. Additionally, it serves as a pH stabilizer in cell culture media and enzymatic assays due to its minimal metal ion binding and low UV absorbance. As a general-purpose laboratory reagent, Tricine is also employed in chemical synthesis as a mild buffering agent or a precursor for specialized derivatives. Its high water solubility and stability make it suitable for both analytical and preparative applications in life sciences and synthetic chemistry.

Physical Properties

Melting Point: 186-188 °C (dec.)

Boiling Point: 500.9 °C at 760 mmHg

Flash Point: 256.7 °C

Density: 1.05 g/mL at 20 °C

Solubility: H2O: 4 M at 20 °C, clear, colorless

Storage: Store at RT.

Analytical Data

Appearance: White/clear crystalline powder