Steppogenin, also known as 2',4',5,7-tetrahydroxyflavanone, is a natural flavonoid compound. It is a key constituent found in various medicinal plants, including *Artocarpus heterophyllus* (jackfruit) and *Morus alba* (mulberry). Its structure is characterized by a flavanone core substituted with four hydroxyl groups at the 2', 4', 5, and 7 positions. Extensive pharmacological research has identified Steppogenin as a bioactive molecule with significant potential in drug discovery. Its most prominent activity is its potent inhibitory effect on tyrosinase, a key enzyme in melanin biosynthesis, making it a candidate for skin-whitening or hyperpigmentation treatment agents. More importantly, studies have demonstrated its promising anti-cancer properties. Steppogenin exhibits cytotoxic effects against various cancer cell lines, including breast, liver, and lung cancers, by inducing apoptosis and cell cycle arrest. It is also investigated for its anti-inflammatory and antioxidant activities. Due to its natural origin and multi-target bioactivity, Steppogenin serves as a valuable lead compound or reference standard in pharmaceutical research, particularly in oncology and dermatology. It is primarily used in biochemical and pharmacological studies to explore its mechanisms and therapeutic potential.