cis-4-Aminocyclohexanol HCl, CAS No. 56239-26-0

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56239-26-0

Catalog No. EBD40444

CAS 56239-26-0

Name cis-4-Aminocyclohexanol HCl

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Basic Information

Synonyms: Cyclohexanol,4-amino-,hydrochloride(1:1),cis- Cyclohexanol,4-amino-,hydrochloride,cis- cis-4-Aminocyclohexanolhydrochloride cis-4-Hydroxycyclohexylaminehydrochloride 4-aminocyclohexan-1-olhydrochloride Cis-4-Amino-CyclohexanolHCl cis-4-AminocyclohexanolHCl cis-4-aminocyclohexan-1-olhydrochloride

Molecular Formula: C6H14ClNO

Molecular Weight: 151.63

MDL Number: MFCD00042624

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

Cis-4-Aminocyclohexanol hydrochloride is a white to off-white crystalline powder. It is a chiral cyclohexane derivative containing both an amino group and a hydroxyl group in a cis configuration. This specific stereochemistry is crucial for its role as a key building block. This compound serves as a vital chiral intermediate in the synthesis of various pharmaceutical agents. Its primary application is in the production of the anti-diabetic drug vildagliptin (Galvus), where it is used to construct the core structure. The cis-aminocyclohexanol moiety is a privileged scaffold in medicinal chemistry, also finding utility in the research and development of other bioactive molecules, including kinase inhibitors and neurological disorder treatments. As a bifunctional chiral synthon, it is valuable in organic synthesis for introducing both amino and hydroxyl functionalities with defined stereochemistry. It should be stored in a cool, dry place, and handled with appropriate personal protective equipment as it may cause skin and eye irritation.

Physical Properties

Melting Point: 225-227 °C

Boiling Point: 241.2 °C at 760 mmHg

Flash Point: 99.7 °C