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    55717-45-8

    Catalog No. EBD10207

    CAS 55717-45-8

    Name 6-Bromopyridin-3-ol

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    Basic Information

    Synonyms: 2-Bromo-5-hydroxypyridine 3-Pyridinol,6-bromo- 6-Bromopyridin-3-ol 6-Brompyridin-3-ol

    Molecular Formula: C5H4BrNO

    Molecular Weight: 174.0

    MDL Number: MFCD04114184

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

    Product Description:
    2-Bromo-5-hydroxypyridine is an organic compound featuring a pyridine ring substituted with a bromine atom at the 2-position and a hydroxyl group at the 5-position. This structure makes it a versatile bifunctional building block, combining the reactivity of an aryl halide (bromide) and a phenol-like hydroxyl group. Its primary application is as a key pharmaceutical intermediate. The bromine atom serves as an excellent site for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig), allowing for the introduction of various aryl, heteroaryl, or amine substituents. The hydroxyl group can be further functionalized (e.g., alkylation, etherification, or used as a directing group in metalation). This compound is frequently employed in the synthesis of biologically active molecules, including potential drug candidates targeting various diseases. As a halogenated heterocycle, it is also a valuable reagent in synthetic chemistry for constructing more complex pyridine derivatives and fused heterocyclic systems used in material science and agrochemical research.
    Physical Properties

    Melting Point: 135.5-136.5°C

    Boiling Point: 373 °C at 760 mmHg

    Flash Point: 179.4 °C

    Density: 1.788 g/cm3

    Analytical Data

    Appearance: Light yellow Crystal

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