14-Desoxy-14-[(2-diethylaminoethyl)mercaptoacetoxy]mutilin, CAS No. 55297-95-5

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55297-95-5

Catalog No. EBD34571

CAS 55297-95-5

Name 14-Desoxy-14-[(2-diethylaminoethyl)mercaptoacetoxy]mutilin

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Basic Information

Synonyms: tiamulin 14-Desoxy-14-[(2-diethylaminoethyl)mercaptoacetoxy]mutilin (1s,2r,3s,4s,6r,7s,14r)-6-((2-diethylaminoethylthio)acetoxy)-3-hydroxy-2,4,7,14-tetramethyl-4-vinyltricyclo(5,4,3,01.8)tetradecan-9-one (4R,5S,6S,8R,9aR,10R)-6-ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propanocyclopenta[8]annulen-8-yl{[2-(diethylamino)ethyl]sulfanyl}acetate (3aS,4R,5S,6S,8R,9R,9aR)-6-ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propanocyclopenta[8]annulen-8-yl{[2-(diethylamino)ethyl]sulfanyl}acetate

Molecular Formula: C28H47NO4S

Molecular Weight: 493.74

Categories: Medicinal Chemistry > APIs and Their Salts > Anti-infectives Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

Tilmicosin is a macrolide antibiotic belonging to the subclass of 16-membered ring macrolides. It is a semi-synthetic derivative of tylosin, characterized by the presence of a 3,5-dimethylpiperidine ring attached to the mycaminose sugar moiety. This structural modification enhances its pharmacokinetic properties and spectrum of activity. Its primary and well-defined application is in veterinary medicine as an active pharmaceutical ingredient (API). Tilmicosin is specifically used for the treatment and control of respiratory diseases in cattle and swine, caused by susceptible pathogens such as *Mycoplasma* spp., *Pasteurella* spp., and *Actinobacillus pleuropneumoniae*. It is administered via injection or in-feed/water formulations due to its poor oral bioavailability in some species. As a key veterinary antibiotic, tilmicosin is also relevant as a pharmaceutical intermediate in its synthesis process. Its core structure, based on the tylosin skeleton, places it within the category of complex heterocyclic intermediates used in the production of advanced macrolide therapeutics.

Physical Properties

Boiling Point: 563 °C at 760 mmHg

Flash Point: 294.3 °C

Density: 1.1 g/cm3