(+)-Angustifoline is a quinolizidine alkaloid naturally found in plants of the *Lupinus* genus, such as *Lupinus angustifolius*. It is a stereoisomer of angustifoline, characterized by its specific three-dimensional configuration. This compound belongs to the class of tetracyclic quinolizidine alkaloids. Its primary interest lies in its biological activity within the realm of medicinal chemistry and neuroscience research. (+)-Angustifoline has been studied for its potential pharmacological effects on the central nervous system. Research indicates it may act as a ligand for nicotinic acetylcholine receptors (nAChRs), suggesting possible applications as a lead compound for developing new therapeutic agents targeting neurological disorders, cognitive function, or addiction. As a plant-derived natural product, it serves as a valuable chemical probe for studying alkaloid biosynthesis and structure-activity relationships. Its isolation and characterization contribute to the understanding of bioactive constituents in traditional medicinal plants.