3-Bromo-5-trifluoromethyl-phenylamine, CAS No. 54962-75-3

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

54962-75-3

Catalog No. EBD21341

CAS 54962-75-3

Name 3-Bromo-5-trifluoromethyl-phenylamine

Get Quote

Basic Information

Synonyms: 3-amino-5-bromobenzotrifluoride 3-Bromo-5-Trifluoromethyl-Phenylamine 3-Bromo-5-trifluoromethylaniline 3-Bromo-5-(trifluoromethyl)aniline 3-bromo-5-(trifluoromethyl)phenylamine benzenamine,3-bromo-5-(trifluoromethyl)-

Molecular Formula: C7H5BrF3N

Molecular Weight: 240.02

MDL Number: MFCD00236205

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

3-Bromo-5-trifluoromethyl-phenylamine is a disubstituted aniline derivative featuring a bromine atom and a trifluoromethyl group at the meta positions relative to the amino group. This molecular architecture combines a reactive aryl bromide handle for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) with a strong electron-withdrawing trifluoromethyl group, which can modulate the lipophilicity and metabolic stability of target molecules. As a key small-molecule fragment, it is widely employed in medicinal chemistry for the synthesis of pharmaceutical candidates, particularly in the development of kinase inhibitors, G protein-coupled receptor (GPCR) modulators, and other central nervous system (CNS) active agents. The compound serves as a versatile building block for constructing complex heterocyclic systems and drug-like scaffolds. Additionally, it functions as a general synthetic intermediate in organic chemistry for preparing agrochemicals and functional materials, where the bromine atom enables further functionalization through metal-catalyzed coupling reactions.

Physical Properties

Boiling Point: 220-223 °C(lit.)

Flash Point: >230 °F

Density: 1.697 g/mL at 25 °C(lit.)

Refractivity: n20/D 1.528(lit.)

Analytical Data

Appearance: 26-36