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    5472-49-1

    Catalog No. EBD48921

    CAS 5472-49-1

    Name 1-(3-Chloropropyl)piperidine hydrochloride

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    Basic Information

    Synonyms: Piperidine,1-(3-chloropropyl)-,hydrochloride 1-(3-Chloropropyl)piperidinehydrochloride NSC28334 Piperidinopropylchloride,hydrochloride 1-(3-chloropropyl)piperidinehydrochloride(1:1)

    Molecular Formula: C8H17Cl2N

    Molecular Weight: 198.13

    MDL Number: MFCD00012838

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    N-(3-Chloropropyl)piperidine hydrochloride is an organic compound featuring a piperidine ring linked to a 3-chloropropyl chain, with the amine functionality protonated as a hydrochloride salt. This bifunctional structure, containing both a secondary amine and a reactive alkyl chloride group, makes it a versatile building block in organic synthesis. Its primary industrial application is as a key pharmaceutical intermediate. It is notably used in the synthesis of various active pharmaceutical ingredients (APIs) and drug candidates. For instance, it serves as a crucial precursor in the production of certain antipsychotic and neuroleptic agents, where the piperidine moiety is a common pharmacophore. The compound acts as a linker to introduce the piperidinylpropyl side chain into target molecules. As a bifunctional synthon, it is also employed in medicinal chemistry research for constructing compound libraries and in the synthesis of other biologically active molecules, including potential receptor ligands. It is typically handled as a solid and requires storage under inert conditions due to its hygroscopic and reactive nature.
    Physical Properties

    Melting Point: 219-223 °C(lit.)

    Boiling Point: 217.3 °C at 760 mmHg

    Flash Point: 85.2 °C

    mg g kg ml l t