3a,6a,7a-Trihydroxy-5b-cholanic acid, CAS No. 547-75-1

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547-75-1

Catalog No. EBD2216613

CAS 547-75-1

Name 3a,6a,7a-Trihydroxy-5b-cholanic acid

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Basic Information

Synonyms: Hyocholic Acid 3a,6a,7a-Trihydroxy-5b-cholanicacid 3α,6α,7α-trihydroxy-5β-cholan-24-oicacid Hyocholicacid 3alpha,6alpha,7alpha-Trihydroxy-5beta-cholan-24-oicacid Cholan-24-oicacid,3,6,7-trihydroxy-,(3alpha,5beta,6alpha,7alpha)- 3,6,12-Trihydroxycholan-24-oicacid

Molecular Formula: C24H40O5

Molecular Weight: 408.57

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Lipids and Derivatives Medicinal Chemistry > Pharmaceutical Excipients > Novel and Functional Excipients

Product Description:

Hyocholic acid (HCA), with CAS number 547-75-1, is a primary bile acid specifically found in pigs. It is a C-6 hydroxylated derivative of chenodeoxycholic acid. Structurally, it is a steroid acid with hydroxyl groups at the 3α, 6α, and 7α positions. Its primary significance lies in biomedical research. HCA has been identified as a potent and selective agonist for the Takeda G protein-coupled receptor 5 (TGR5), a key bile acid receptor involved in glucose metabolism and energy homeostasis. This makes it a valuable tool compound for studying metabolic diseases like diabetes and obesity. Recent research also explores its potential as a biomarker and its role in modulating gut microbiota. Beyond research reagents, due to its biological activity and origin, hyocholic acid and its derivatives are investigated for potential applications in pharmaceutical formulations, aligning with the exploration of novel bile acid-based drug delivery systems and functional excipients.

Physical Properties

Boiling Point: 565.7 °C at 760 mmHg

Flash Point: 310 °C

Density: 1.184 g/cm3