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    5467-74-3

    Catalog No. EBD435374

    CAS 5467-74-3

    Name 4-Bromophenylboronic acid

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    Basic Information

    Synonyms: 4-Bromophenylboronicacid dihydroxy-4-bromophenylborane p-Bromophenylboronicacid 4-BROMOPHENYLBORICACIDANHYDRIDE 4-bromo-phenylboronicacid: 4-Bromobenzeneboronicacid

    Molecular Formula: C6H6BBrO2

    Molecular Weight: 200.83

    MDL Number: MFCD00002104

    Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters

    Product Description:
    4-Bromophenylboronic acid is a bifunctional organoboron compound featuring a bromine atom at the para position of a phenyl ring and a boronic acid group. It appears as a white to off-white crystalline powder with a molecular weight of 200.83 g/mol. The compound is stable under normal conditions but should be stored in a cool, dry place away from moisture. This compound serves as a versatile building block in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions, where the boronic acid group facilitates carbon-carbon bond formation with aryl or vinyl halides. The bromine substituent allows for further functionalization, making it a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and advanced materials. In medicinal chemistry, it is frequently employed to construct biaryl structures found in drug candidates targeting oncology, inflammation, and central nervous system disorders. Additionally, 4-bromophenylboronic acid is utilized in the preparation of molecular sensors, liquid crystals, and polymer additives. Its dual reactivity enables sequential coupling strategies, enhancing its utility in complex molecule assembly. Safety precautions include avoiding inhalation or skin contact, as it may cause irritation.
    Physical Properties

    Melting Point: 284-288 °C(lit.)

    Boiling Point: 315 °C at 760 mmHg

    Flash Point: 144.3 °C

    Density: 1.67 g/cm3

    Storage: 0-6°C

    Analytical Data

    Appearance: white to light yellow crystal powder

    mg g kg ml l t