2-Hydroxy-5-nitropyridine, CAS No. 5418-51-9

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5418-51-9

Catalog No. EBD541085

CAS 5418-51-9

Name 2-Hydroxy-5-nitropyridine

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Basic Information

Synonyms: 5-Nitro-2-pyridinol 5-Nitro-2(1H)-pyridone 5-Nitro-2-hydroxypyridine 2-hydroxy-5-nitropyridine 5-nitropyridin-2(1H)-one 5-nitropyridin-2(3H)-one 2-Pyridinol,5-nitro-

Molecular Formula: C5H4N2O3

Molecular Weight: 140.1

MDL Number: MFCD00006276

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

2-Hydroxy-5-nitropyridine is a heterocyclic organic compound featuring a pyridine ring substituted with a hydroxyl group at the 2-position and a nitro group at the 5-position. This structure makes it a versatile building block in organic synthesis. Its primary application is as a key intermediate in the synthesis of various pharmaceuticals and bioactive molecules. The nitro group can be readily reduced to an amine, which can then be further functionalized. For instance, it serves as a crucial precursor in the synthesis of certain antibacterial agents and other nitrogen-containing heterocyclic compounds with potential biological activity. Due to its bifunctional nature (hydroxy and nitro substituents), it is a valuable synthon for constructing more complex molecular architectures, particularly in medicinal chemistry research for developing new drug candidates.

Physical Properties

Melting Point: 188-191 °C(lit.)

Boiling Point: 334 °C at 760 mmHg

Flash Point: 155.8 °C

Density: 1.44 g/cm3

Analytical Data

Appearance: light yellow to beige crystalline powder