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    53786-28-0

    Catalog No. EBD53891

    CAS 53786-28-0

    Name 5-Chloro-1-(piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

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    Basic Information

    Synonyms: 5-Chloro-1-(piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one 5-chloro-1,3-dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one 2H-benzimidazol-2-one,5-chloro-1,3-dihydro-1-(4-piperidinyl)- 5-Chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one 5-Chloro-1-(4-Piperidyl)-2-Benzimidazolinone

    Molecular Formula: C12H14ClN3O

    Molecular Weight: 251.71

    MDL Number: MFCD02093793

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

    Product Description:
    5-Chloro-1-(4-piperidinyl)-2-benzimidazolinone is a heterocyclic organic compound featuring a benzimidazolinone core substituted with a chloro group and a piperidinyl moiety. This specific structural motif is characteristic of compounds designed to interact with biological targets in the central nervous system. This compound is primarily recognized as a key intermediate in the synthesis of paliperidone, an important atypical antipsychotic drug used in the treatment of schizophrenia and schizoaffective disorder. The piperidine and benzimidazolinone rings are crucial pharmacophores for binding to dopamine and serotonin receptors, which underpins the drug's therapeutic mechanism of action. Its synthesis and purity are critical steps in the manufacturing process of the active pharmaceutical ingredient (API). As a specialized pharmaceutical intermediate, its production and handling are governed by strict quality control standards to ensure the safety and efficacy of the final drug product. It is not typically employed as a general-purpose building block in broad synthetic chemistry.
    Physical Properties

    Melting Point: 228-231 °C(lit.)

    Density: 1.323 g/cm3

    mg g kg ml l t