6-chloro-pyridin-3-ylamine, CAS No. 5350-93-6

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5350-93-6

Catalog No. EBD472392

CAS 5350-93-6

Name 6-chloro-pyridin-3-ylamine

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Basic Information

Synonyms: 5-amino-2-cholorpyridine 6-chloro-pyridin-3-ylamine 2-Chloro-5-aminopyridine 6-Chloropyridin-3-Amine 3-Pyridinamine,6-Chloro- 3-Amino-6-Chloropyridine Timtec-BbSbb004234 AminoChloropyridine 6-Chloro-3-Pyridinamine 3-Pyridinamine,6-Chloro-(9ci) Lcx-108 5-Amino-2-Chloropyridine

Molecular Formula: C5H5ClN2

Molecular Weight: 128.56

MDL Number: MFCD00006243

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

2-Chloro-5-aminopyridine is an important heterocyclic aromatic compound featuring both an amino group and a chlorine atom on the pyridine ring. This bifunctional structure makes it a versatile and valuable building block in organic synthesis. Its primary and most significant application is as a key pharmaceutical intermediate. It serves as a crucial precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly in the development of anti-infective and anti-inflammatory drugs. The presence of both nucleophilic (amino) and electrophilic (chloro) sites allows for sequential and regioselective functionalization, enabling the construction of complex drug molecules. Due to its fundamental structure, it is also widely used as a general-purpose organic synthesis building block in research and development beyond pharmaceuticals, contributing to the synthesis of agrochemicals, ligands, and functional materials.

Physical Properties

Melting Point: 81-83 °C(lit.)

Boiling Point: 292.6 °C at 760 mmHg

Flash Point: 130.7 °C

Density: 1.326 g/cm3

Analytical Data

Appearance: light yellow to brown crystalline powder