Boc-N-Me-Leu-OH, CAS No. 53363-89-6

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53363-89-6

Catalog No. EBD2198075

CAS 53363-89-6

Name Boc-N-Me-Leu-OH

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Basic Information

Synonyms: Boc-N-Me-Leu-OH boc-N-methyl-L-leucine N-alpha-t-butyloxycabonyl-N-alpha-Methyl-L-leucine N-(tert-butoxycarbonyl)-N-methylleucine N-(tert-butoxycarbonyl)-N-methyl-L-leucine Tyr(me)

Molecular Formula: C12H23NO4

Molecular Weight: 245.32

MDL Number: MFCD00038522

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

Product Description:

N-Boc-N-methyl-L-leucine is a protected amino acid derivative. It features a tert-butoxycarbonyl (Boc) group protecting the secondary amine of N-methyl-L-leucine. This compound is a white to off-white crystalline powder. Its primary application is as a crucial building block in solid-phase peptide synthesis (SPPS) and medicinal chemistry. The Boc group serves as a base-labile protecting group for the amine functionality, allowing for orthogonal deprotection strategies during the sequential assembly of peptide chains. N-methylation of the amide bond is a common strategy to enhance the metabolic stability, membrane permeability, and bioavailability of therapeutic peptides, making this derivative valuable for developing peptide-based drugs and peptidomimetics. This reagent is widely used in research and development for constructing complex peptides, including those with potential pharmaceutical activities. Standard safety precautions for handling laboratory chemicals should be observed.

Physical Properties

Melting Point: 55-60 °C

Boiling Point: 338.2 °C at 760 mmHg

Flash Point: 158.3 °C

Density: 1.053 g/cm3

Storage: Store at RT.

Analytical Data

Appearance: White powder