Boc-trans-4-aminocyclohexanecarboxylic acid, CAS No. 53292-89-0

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53292-89-0

Catalog No. EBD40565

CAS 53292-89-0

Name Boc-trans-4-aminocyclohexanecarboxylic acid

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Basic Information

Synonyms: trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylicacid cyclohexanecarboxylicacid,4-[[(1,1-dimethylethoxy)carbonyl]amino]-,trans- trans-4-[(tert-Butoxycarbonyl)amino]cyclohexanecarboxylicacid Boc-trans-4-aminocyclohexane-1-carboxylicacid Boc-1,4-Trans-Achc-OH trans-4-[(N-tert-butoxycarbonyl)amino]-1-cyclohexanecarboxylicacid trans-4-(boc-amino)cyclohexanecarboxylicacid Boc-Trans-4-AminocyclohexanecarboxylicAcid

Molecular Formula: C12H21NO4

Molecular Weight: 243.3

Categories: Synthetic Chemistry > Organic Building Blocks > Amines Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

Product Description:

Boc-trans-4-aminocyclohexanecarboxylic acid is a chiral building block featuring a trans-configured cyclohexane ring with a tert-butoxycarbonyl (Boc)-protected amino group and a carboxylic acid moiety. This rigid, non-natural amino acid derivative is widely utilized in medicinal chemistry as a key intermediate for the synthesis of peptide mimetics, kinase inhibitors, and other bioactive molecules. Its stereochemical purity and orthogonal protecting groups enable selective functionalization in drug discovery pipelines. As a versatile synthetic intermediate, it serves as a precursor for constructing constrained cyclic scaffolds in pharmaceutical candidates targeting central nervous system disorders, oncology, and metabolic diseases. The compound is also employed in solid-phase peptide synthesis and as a spacer unit in PROTAC development. Its stability under standard coupling conditions makes it a preferred choice for library synthesis and lead optimization.

Physical Properties

Boiling Point: 396.7 °C at 760 mmHg

Flash Point: 193.7 °C

Density: 1.13 g/cm3