2-(2-Fluorophenyl)ethanamine, CAS No. 52721-69-4

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52721-69-4

Catalog No. EBD49997

CAS 52721-69-4

Name 2-(2-Fluorophenyl)ethanamine

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Basic Information

Synonyms: 2-(2-fluorophenyl)ethanamine 2-(2-fluorophenyl)ethanaminium 2-Fluoro-benzeneethanamine 2-Fluorophenethylamine 2-(2-Fluorophenyl)-ethylamine benzeneethanamine,2-fluoro- o-fluorophenethylamine o-fluorophenylethylamine 2-fluorobenzeneethanamine 2-(2-fluorophenyl)ethylamine

Molecular Formula: C8H10FN

Molecular Weight: 139.17

MDL Number: MFCD00075502

Categories: Synthetic Chemistry > Organic Building Blocks > Amines Medicinal Chemistry > Pharmaceutical Intermediates > Other Pharmaceutical Intermediates

Product Description:

2-Fluorophenethylamine is an organic compound featuring a phenethylamine backbone with a fluorine substituent at the ortho position of the aromatic ring. It is a versatile building block in organic synthesis, primarily valued for its amine functional group and the electron-withdrawing fluorine atom, which can influence reactivity and metabolic stability in derived molecules. Its primary application is as a key synthetic intermediate in pharmaceutical research and development. The fluorinated phenethylamine scaffold is a common motif in the design of bioactive compounds, including potential central nervous system (CNS) agents, receptor ligands, and other pharmacologically active molecules. The fluorine atom is often introduced to modulate lipophilicity, binding affinity, and to block metabolic sites. As a basic amine, it requires careful handling under inert conditions to prevent degradation. It serves as a fundamental starting material for constructing more complex chemical architectures in medicinal chemistry programs.

Physical Properties

Boiling Point: 64 °C/0.6 mmHg(lit.)

Flash Point: 77 °C

Density: 1.066 g/mL at 25 °C(lit.)

Refractivity: n20/D 1.51(lit.)

Safety Information

Packing Level: II

Hazard Category: 8

Transport Codes: 2735PSN1

Analytical Data

Appearance: clear pale yellow to slightly pink liquid