3'-Amino-2',3'-dideoxythymidine, CAS No. 52450-18-7

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52450-18-7

Catalog No. EBD42704

CAS 52450-18-7

Name 3'-Amino-2',3'-dideoxythymidine

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Basic Information

Synonyms: 3'-amino-3'-deoxythymidine 3'-Aminothymidine Thymidine,3'-amino-3'-deoxy- 3'-Amino-2',3'-dideoxythymidine 3'-NH2-ddT 1-[(2R,4S,5S)-4-Amino-5-(Hydroxymethyl)Oxolan-2-Yl]-5-Methylpyrimidine-2,4-Dione 3'-Deoxy-3'-aminothymidine

Molecular Formula: C10H15N3O4

Molecular Weight: 241.24

MDL Number: MFCD00038057

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides

Product Description:

3'-Amino-2',3'-dideoxythymidine is a synthetic nucleoside analogue characterized by the absence of hydroxyl groups at the 2' and 3' positions of the sugar ring, which is replaced by an amino group at the 3' position. This structural modification makes it a dideoxynucleoside derivative of thymidine. This compound serves as a crucial intermediate in the synthesis of various nucleoside reverse transcriptase inhibitors (NRTIs), a major class of antiviral drugs. It is specifically used in the research and development of anti-HIV agents. The 3'-amino group provides a key handle for further chemical modifications to create prodrugs or to link to other pharmacophores, enhancing drug delivery or targeting properties. As a modified nucleoside, it falls under the category of life science building blocks used in medicinal chemistry and biochemical research. Its primary utility lies in constructing more complex antiviral compounds rather than as a therapeutic agent itself.

Physical Properties

Melting Point: 161-162 °C

Density: 1.36 g/cm3