SUC-ALA-ALA-ALA-PNA, CAS No. 52299-14-6

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52299-14-6

Catalog No. EBD3059835

CAS 52299-14-6

Name SUC-ALA-ALA-ALA-PNA

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Basic Information

Synonyms: STANA EINECS257-823-5 SUC-ALA-ALA-ALA-PNA SUCCINYL-TRIALANINE-4-NITROANILIDE SUCCINYL-ALA-ALA-ALA-P-NITROANILIDE ELASTASESUBSTRATEVIII,COLORIMETRIC N-SUCCINYL-ALA-ALA-ALAP-NITROANILIDE N-SUCCINYL-TRI-L-ALANINE4-NITROANILIDE N-SUCCINYL-(L-ALA)3-P-NITROANILIDE**03-32-0009** SUCCINYL-L-ALANYL-L-ALANYL-L-ALANINEP-NITROANILIDE N-succinyl-L-alanyl-L-alanyl-L-alanine4-nitroanilide N-Succinyl-Ala-Ala-Ala-p-nitroanilide N-(3-carboxypropanoyl)-L-alanyl-L-alanyl-N-(4-nitrophenyl)-L-alaninamide

Molecular Formula: C19H25N5O8

Molecular Weight: 451.43

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Peptides and Peptidomimetics Synthetic Chemistry > Organic Building Blocks > Other Organic Building Blocks

Product Description:

Suc-Ala-Ala-Ala-pNA is a synthetic tetrapeptide substrate, where the N-terminus is blocked by a succinyl (Suc) group and the C-terminus is linked to a para-nitroaniline (pNA) chromogenic group. This specific sequence and modification make it a highly specialized biochemical tool. Its primary and well-established application is as a chromogenic substrate for the detection and kinetic study of various serine proteases, most notably elastase and subtilisin. Upon enzymatic cleavage of the peptide bond adjacent to the pNA group, free p-nitroaniline is released, resulting in a measurable increase in absorbance at 405-410 nm. This property makes it an essential reagent in enzymology research, high-throughput screening for protease inhibitors, and diagnostic assay development. While its core utility is in life science research, the molecule itself, as a defined peptide sequence with a protecting group and a reporter tag, can also be considered a specialized organic synthesis building block for constructing more complex peptide-based probes or inhibitors.

Physical Properties

Boiling Point: 923.5 °C at 760 mmHg

Flash Point: 512.3 °C

Density: 1.37 g/cm3

Storage: 2-8°C