hematoxylin, CAS No. 517-28-2

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517-28-2

Catalog No. EBD2184769

CAS 517-28-2

Name hematoxylin

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Basic Information

Synonyms: (6aR,11bS)-7,11b-Dihydroindeno[2,1-c]chromene-3,4,6a,9,10(6H)-pentol 517-28-2 benz[b]indeno[1,2-d]pyran-3,4,6a,9,10(6H)-pentol,7,11b-dihydro-,(6aR,11bS)- cis-(+)-7,11b-dihydrobenz[b]indeno[1,2-d]pyran-3,4,6a,9,10(6H)-pentol hematoxiline Hematoxylin(C.I.75290) hydroxybrasilin hydroxybrazilin (6aS,11bS)-7,11b-dihydroindeno[2,1-c]chromene-3,4,6a,9,10(6H)-pentol (+)-(11bc)-7,11b-Dihydro-indeno[2,1-c]chromen-3,4,6ar,9,10-pentaol

Molecular Formula: C16H14O6

Molecular Weight: 302.28

MDL Number: MFCD00078111

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Phytochemicals and Natural Products Synthetic Chemistry > Analytical Chemistry Reagents > Indicators

Product Description:

Hematoxylin is a natural phenolic compound extracted from the heartwood of the logwood tree (*Haematoxylum campechianum*). It is a heterocyclic organic molecule that is not used directly but is oxidized to form its active counterpart, hematein. Hematein, in combination with a metallic mordant (typically aluminum or iron salts), forms a deep blue-black or brown complex. The primary and most significant application of hematoxylin is as a histological stain in biological and medical research. It is the core component of the "H&E stain" (Hematoxylin and Eosin), the most widely used staining technique in histopathology. In this context, hematoxylin (as hematein-mordant complex) selectively binds to basophilic structures, such as nucleic acids (DNA and RNA) in the cell nucleus and acidic components of cartilage, staining them blue-purple. This allows for the clear visualization of cellular and tissue architecture under a microscope, which is fundamental for disease diagnosis and biological studies. Beyond its dominant role in histology, hematoxylin also finds use as a pH indicator, changing color in aqueous solutions. It has been used in dyeing textiles and as a component in some inks. Due to its natural origin and specific staining mechanism, it is not considered a general-purpose synthetic building block but a specialized biological reagent and dye.

Physical Properties

Melting Point: 200 °C (dec.)(lit.)

Boiling Point: 579.9 °C at 760 mmHg

Flash Point: 304.5 °C

Density: 1.709 g/cm3

Solubility: SOLUBLE IN HOT WATER

Storage: Store at RT.

Analytical Data

Appearance: brownish crystalline powder