2-Acetylbutyrolactone, CAS No. 517-23-7

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517-23-7

Catalog No. EBD37679

CAS 517-23-7

Name 2-Acetylbutyrolactone

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Basic Information

Synonyms: ABL 3-Acetyl-4,5-dihydro-2(3H)-furanone alpha-Acetyl-gamma-butyrolactone 2-Acetyl-Sulfo-gamma-butyrolactone 3-acetyldihydrofuran-2(3H)-one (3R)-3-acetyldihydrofuran-2(3H)-one (3S)-3-acetyldihydrofuran-2(3H)-one α-Acetyl-γ-butyrrolactone 3-Acetyl-dihydro-furan-2-one 3-Acetyl-dihydro-2(3H)-furanone 2-Acetyl-gamma-butyrolactone 3-Acetyloxolane-2-one 2-Acetylbutyrolactone

Molecular Formula: C6H8O3

Molecular Weight: 128.13

MDL Number: MFCD00005394

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Other Organic Building Blocks

Product Description:

2-Acetylbutyrolactone, also known as α-acetyl-γ-butyrolactone, is a versatile heterocyclic compound featuring a γ-butyrolactone ring substituted with an acetyl group. It serves as a crucial synthetic intermediate in the pharmaceutical industry. Its primary application is in the synthesis of pyrrolidine and pyrrolidone derivatives, which are core structures in numerous bioactive molecules. Notably, it is a key starting material for the production of racetam-class nootropic drugs, such as piracetam and aniracetam, which are used to enhance cognitive function. The compound's reactivity allows for further functionalization, making it a valuable building block for constructing complex nitrogen-containing heterocycles. Beyond pharmaceuticals, 2-acetylbutyrolactone finds use as a flavoring agent and fragrance ingredient due to its caramel-like odor. It is also employed in organic synthesis as a precursor for various fine chemicals.

Physical Properties

Boiling Point: 107-108 °C/5 mmHg(lit.)

Flash Point: 113 °C

Density: 1.19 g/mL at 25 °C(lit.)

Solubility: 310 g/L (20 ºC)

Refractivity: n20/D 1.459(lit.)

Analytical Data

Appearance: Colorless to light yellow liquid