4-Bromo-2-fluorotoluene, CAS No. 51436-99-8

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51436-99-8

Catalog No. EBD970660

CAS 51436-99-8

Name 4-Bromo-2-fluorotoluene

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Basic Information

Synonyms: Bromofluorotoluene7 2-Fluoro-4-bromotoluene 4-Bromo-2-fluorotoluene,98% 4-Bromo-2-fluorotoluene 4-bromo-2-fluorotluene 4-bromo-2-flurotoluene 2-bromo-2-fluorotoluene 4-bromo-z-fluorotoluene 1-methyl-2-fluoro-4-bromobenzene 4-bromo-2-fluoro-1-methyl-benzene

Molecular Formula: C7H6BrF

Molecular Weight: 189.02

MDL Number: MFCD00013551

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

Product Description:

4-Bromo-2-fluorotoluene is a disubstituted benzene derivative featuring a bromine atom at the para position and a fluorine atom at the ortho position relative to a methyl group. This molecular structure combines a reactive bromine handle for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) with a fluorine substituent that can modulate lipophilicity and metabolic stability in target molecules. As a versatile halogenated aromatic building block, it is widely employed in organic synthesis for constructing complex pharmaceuticals, agrochemicals, and functional materials. In medicinal chemistry, it serves as a key intermediate for developing drug candidates targeting central nervous system disorders and inflammatory diseases, where the fluorine atom often enhances binding affinity and pharmacokinetic properties. The compound is typically handled as a colorless to pale yellow liquid under standard conditions and requires standard precautions for halogenated aromatics. Its dual functionality makes it particularly valuable for late-stage diversification in drug discovery pipelines.

Physical Properties

Boiling Point: 68 °C (8 mmHg)

Flash Point: 76 °C

Density: 1.492 g/mL at 25 °C(lit.)

Solubility: INSOLUBLE

Refractivity: n20/D 1.529(lit.)

Analytical Data

Appearance: colorless to light yellow liquid