American ginseng extract is a complex mixture of bioactive compounds derived from the roots of *Panax quinquefolius* L. Its composition is characterized by a unique profile of ginsenosides (triterpene saponins), with a higher ratio of Rb1 to Rg1 compared to Asian ginseng (*Panax ginseng*). It also contains polysaccharides, polyacetylenes, peptides, and various other phytochemicals. The primary application of American ginseng extract is in the health supplement and nutraceutical industries. It is widely consumed for its purported adaptogenic properties, which are believed to help the body resist stress, enhance immune function, improve cognitive performance, and increase energy levels. Specific ginsenosides, such as Rb1 and Re, are associated with neuroprotective, anti-fatigue, and hypoglycemic effects. It is formulated into capsules, tablets, teas, and functional beverages. Beyond dietary supplements, American ginseng extract is also incorporated into cosmetic formulations for its antioxidant and skin-soothing properties. Its use is supported by a long history in traditional medicine and a growing body of modern pharmacological research investigating its mechanisms related to modulating the hypothalamic-pituitary-adrenal axis, inflammatory pathways, and cellular energy metabolism.