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    50488-44-3

    Catalog No. EBD5198

    CAS 50488-44-3

    Name 4-Bromo-2-methylquinoline

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    Basic Information

    Molecular Formula: C10H8BrN

    Molecular Weight: 222.08

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

    Product Description:
    4-Bromo-2-methylquinoline is a halogenated heterocyclic compound featuring a quinoline core substituted with a bromine atom at the 4-position and a methyl group at the 2-position. It is a solid at room temperature and serves as a versatile synthetic building block. Its primary application is in pharmaceutical research and development as a key intermediate. The bromine atom at the 4-position is a reactive site amenable to various cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig), allowing for the introduction of diverse functional groups. This makes it a valuable precursor for constructing more complex quinoline derivatives, which are privileged scaffolds in medicinal chemistry with potential biological activities. As a brominated quinoline derivative, it is a fundamental organic synthesis intermediate. Its structure places it within the broader category of halogenated aromatic and heteroaromatic compounds, which are essential for constructing carbon-carbon and carbon-heteroatom bonds in synthetic chemistry.
    Physical Properties

    Boiling Point: 300.661 °C at 760 mmHg

    Flash Point: 135.635 °C

    Density: 1.488 g/cm3

    mg g kg ml l t