6-Hydroxynicotinic acid, CAS No. 5006-66-6

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5006-66-6

Catalog No. EBD40386

CAS 5006-66-6

Name 6-Hydroxynicotinic acid

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Basic Information

Synonyms: 2-Hydroxypyridine-5-carboxylicacid 6-oxonicotinicacid 2-hydroxy-5-pyridinecarboxylicacid 6-hydroxynicotinicacid 6-oxo-1,6-dihydropyridine-3-carboxylate

Molecular Formula: C6H5NO3

Molecular Weight: 139.11

MDL Number: MFCD00006277

Categories: Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters Synthetic Chemistry > Organic Building Blocks > Phenols and Ethers Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

6-Hydroxynicotinic acid is a heterocyclic compound featuring a pyridine ring substituted with a hydroxyl group at the 6-position and a carboxylic acid group at the 3-position. It exists predominantly in its keto form (2-oxo-1,2-dihydropyridine-3-carboxylic acid) and serves as a key building block in medicinal chemistry. This compound is primarily utilized as an intermediate in the synthesis of pharmaceuticals, including nicotinic acid derivatives and potential drug candidates targeting neurological and metabolic disorders. It also acts as a precursor for bioactive molecules and agrochemicals. In biochemical research, it is employed as a ligand or scaffold for studying enzyme interactions, particularly those involving nicotinic acid receptors. With a molecular weight of 139.11 g/mol and a melting point around 300буC (decomposition), it is a stable solid under normal conditions. Its dual functional groups enable versatile chemical modifications, making it valuable for both drug discovery and synthetic chemistry applications.

Physical Properties

Melting Point: >300 °C(lit.)

Boiling Point: 384 °C at 760 mmHg

Flash Point: 186 °C

Density: 1.451 g/cm3

Analytical Data

Appearance: Off-white powder