Piperidine-3-carboxylic acid, CAS No. 498-95-3

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498-95-3

Catalog No. EBD24696

CAS 498-95-3

Name Piperidine-3-carboxylic acid

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Basic Information

Synonyms: l-nipecoticacid d(-)-nipecoticacid (\+/-)-nipecoticacid (-)-d-nipecoticacid Piperidine-3-carboxylicacid 3-Piperidinecarboxylicacid Piperidin-3-carboxylicacid H-DL-Nip-OH~(+/-)-Piperidine-3-carboxylicacid Nipecoticacid DL-Nipecoticacid h-nip-oh h-d-nipc-oh h-dl-nipc-oh h-dl-pic(3)-oh d-nipecoticacid

Molecular Formula: C6H11NO2

Molecular Weight: 129.16

MDL Number: MFCD00005992

Categories: Synthetic Chemistry > Organic Building Blocks > Amines Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

Piperidine-3-carboxylic acid is a heterocyclic compound featuring a piperidine ring with a carboxylic acid substituent at the 3-position. It exists as a white to off-white crystalline solid and is a key building block in organic synthesis. Structurally, it is a nipecotic acid derivative, serving as a fundamental scaffold for constructing more complex molecules. This compound is primarily utilized as a pharmaceutical intermediate, particularly in the synthesis of central nervous system (CNS) active agents, including GABA uptake inhibitors and various analgesics. Its piperidine core is a common motif in drug discovery, making it valuable for developing therapeutic candidates targeting neurological disorders. Additionally, it functions as a versatile synthetic building block for preparing amides, esters, and other derivatives in medicinal chemistry research. As a general synthetic intermediate, it is also employed in the preparation of specialty chemicals and agrochemicals. The compound is stable under normal storage conditions but should be handled with standard laboratory safety practices. Its dual role as both a targeted pharmaceutical intermediate and a general organic synthesis building block underscores its importance in chemical research and development.

Physical Properties

Melting Point: 261 °C (dec.)(lit.)

Boiling Point: 265.8 °C at 760 mmHg

Flash Point: 114.5 °C

Density: 1.125 g/cm3

Storage: Store at 0-5°C

Analytical Data

Appearance: off-white to pale yellow-beige powder