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    49669-13-8

    Catalog No. EBD18740

    CAS 49669-13-8

    Name 2-Acetyl-6-bromopyridine

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    Basic Information

    Synonyms: 2-Bromo-6-Acetylpyridine 1-(6-bromopyridin-2-yl)ethanone 2-Acetyl-6-bromopyridine

    Molecular Formula: C7H6BrNO

    Molecular Weight: 200.03

    MDL Number: MFCD00272200

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

    Product Description:
    2-Acetyl-6-bromopyridine is an organic compound featuring a pyridine ring substituted with an acetyl group at the 2-position and a bromine atom at the 6-position. This structure combines a reactive halogen (bromine) with a carbonyl group, making it a versatile bifunctional building block. Its primary application is as a key pharmaceutical intermediate in medicinal chemistry research and drug development. The bromine atom serves as an excellent site for cross-coupling reactions (e.g., Suzuki, Stille), while the acetyl group can be further modified or used in condensation reactions. This makes it particularly valuable for constructing complex heterocyclic scaffolds found in bioactive molecules, including potential kinase inhibitors and other therapeutic agents. As a commercially available synthon, it is widely used in academic and industrial laboratories for the synthesis of novel chemical entities. Handling requires standard precautions for halogenated and pyridine-based compounds, including the use of appropriate personal protective equipment.
    Physical Properties

    Melting Point: 51-55 °C(lit.)

    Boiling Point: 271.2 °C at 760 mmHg

    Flash Point: 117.8 °C

    Density: 1.534 g/cm3

    mg g kg ml l t