(-)-Epicatechin is a natural flavan-3-ol belonging to the catechin subclass of flavonoids. It is a stereoisomer of catechin, differing in the configuration at the 3-position. This compound is widely found in various plants, notably in green tea, cocoa, grapes, and apples. Its primary significance lies in its potent biological activities and health benefits. (-)-Epicatechin is a major bioactive component in many traditional medicines and functional foods. It exhibits strong antioxidant properties by scavenging free radicals and chelating metal ions. Research indicates potential therapeutic applications in cardiovascular health, neuroprotection, diabetes management, and anti-inflammatory responses. It is also studied for its role in modulating mitochondrial biogenesis and improving exercise performance. Due to its diverse pharmacological profile, (-)-Epicatechin is a key compound in nutraceutical and pharmaceutical research. It serves as a reference standard, a lead compound for drug development, and an active ingredient in dietary supplements. Its safety profile is generally considered favorable, contributing to its widespread use in health-related products.