1-methyl-5-pyridin-3-ylpyrrolidin-2-one, CAS No. 486-56-6

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486-56-6

Catalog No. EBD70595

CAS 486-56-6

Name 1-methyl-5-pyridin-3-ylpyrrolidin-2-one

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Basic Information

Synonyms: (-)-cotinine (S)-(-)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone (5R)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one (5S)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one 1-methyl-5-(3-pyridyl)pyrrolidin-2-one 1-methyl-5-pyridin-3-ylpyrrolidin-2-one

Molecular Formula: C10H12N2O

Molecular Weight: 176.22

MDL Number: MFCD00077696

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Other Biochemicals and Life Science Reagents

Product Description:

1H-Pyrrolo[2,3-b]pyridine, also known as 7-azaindole, is a bicyclic heteroaromatic compound featuring a fused pyrrole and pyridine ring system. It serves as a privileged scaffold in medicinal chemistry due to its structural similarity to purine bases, enabling it to act as a bioisostere for indole and other heterocycles. Its primary application is as a versatile building block for the synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (APIs). It is a key structural motif found in numerous drug candidates and marketed drugs targeting protein kinases, such as certain tyrosine kinase inhibitors used in oncology. The scaffold is also utilized in the development of compounds for central nervous system (CNS) disorders and anti-inflammatory agents. Beyond drug discovery, 7-azaindole derivatives find use in materials science, particularly as ligands in coordination chemistry and as precursors for organic light-emitting diodes (OLEDs). Its unique photophysical properties make it valuable for constructing fluorescent probes and functional materials.

Physical Properties

Melting Point: 40-42 °C(lit.)

Boiling Point: 250 °C/150 mmHg(lit.)

Flash Point: 110 °C

Storage: 2-8°C