2-Chloro-1H-benzo[d]imidazole, CAS No. 4857-06-1

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

4857-06-1

Catalog No. EBD17389

CAS 4857-06-1

Name 2-Chloro-1H-benzo[d]imidazole

Get Quote

Basic Information

Synonyms: 2-Chlorobenzimidazole 1H-Benzimidazole,2-chloro- 2-chloro-1h-benzimidazol Benzimidazole,2-chloro- TIMTEC-BBSBB006585 2-CHLORO-1H-BENZIMIDAZOLE 2-CHLORO-1H-BENZOIMIDAZOLE AKOSB028974 2-Chloro-1H-benzo[d]imidazole

Molecular Formula: C7H5ClN2

Molecular Weight: 152.58

MDL Number: MFCD00051944

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

2-Chlorobenzimidazole is a heterocyclic organic compound featuring a fused benzene and imidazole ring system with a chlorine substituent at the 2-position. It serves as a versatile and crucial synthetic building block in medicinal chemistry. Its primary and most significant application is as a key intermediate in the synthesis of various pharmacologically active benzimidazole derivatives. These include proton pump inhibitors (e.g., omeprazole, lansoprazole), anthelmintic drugs (e.g., albendazole, mebendazole), and other therapeutic agents targeting viral infections, cancer, and inflammation. The chlorine atom at the 2-position is a reactive handle that facilitates further functionalization, making it a preferred starting material. Beyond its role as a pharmaceutical intermediate, 2-chlorobenzimidazole is also utilized in the synthesis of organic ligands, dyes, and corrosion inhibitors. It is a solid at room temperature and requires careful handling due to its potential irritant properties.

Physical Properties

Melting Point: 207-211 °C(lit.)

Boiling Point: 328.5 °C at 760 mmHg

Flash Point: 182.5 °C

Density: 1.425 g/cm3

Analytical Data

Appearance: beige to brown crystalline powder