2,2-dihydroxy-1,3-Indandione, CAS No. 485-47-2

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485-47-2

Catalog No. EBD36775

CAS 485-47-2

Name 2,2-dihydroxy-1,3-Indandione

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Basic Information

Synonyms: Ninhydrin 1,2,3-Indantrionemonohydrate~1,2,3-Triketohydrindenemonohydrate 1,2,3-Triketohydrindene 1H-Indene-1,2,3-trione 2,2-Dihydroxy-1H-indene-1,3(2H)-dione Ninhydrin(1.06762) Ninhydrinsprayrefill 1,2,3-Indantrione 1H-indene-1,2,3-trionehydrate(1:1) Ninhydrincrystals 1,2,3-indantrionemonohydrate

Molecular Formula: C9H6O4

Molecular Weight: 178.14

MDL Number: MFCD00003791

Categories: Synthetic Chemistry > Analytical Chemistry Reagents > Indicators

Product Description:

2,2-Dihydroxy-1,3-indandione, commonly known as ninhydrin, is a triketone hydrate derivative of indane. It appears as a white to pale yellow crystalline solid and is highly soluble in water and polar organic solvents. Its structure features a fused indane ring system with two geminal hydroxyl groups and a ketone, enabling its characteristic reaction with primary amines. Ninhydrin is primarily utilized as a chromogenic reagent for the detection and quantification of amino acids, peptides, and proteins. Upon reaction with primary amines, it produces a deep purple color known as Ruhemannбпs purple, which is measured spectrophotometrically at around 570 nm. This property makes it indispensable in analytical chemistry for thin-layer chromatography (TLC) visualization, forensic science for latent fingerprint development, and biochemical assays for amino acid analysis. Additionally, ninhydrin serves as a key reagent in clinical diagnostics for monitoring amino acid metabolism disorders and in pharmaceutical research for quality control of amine-containing compounds. It is also employed in the synthesis of certain heterocyclic compounds and as a building block for fluorescent probes. Due to its sensitivity and specificity, it remains a standard tool in both academic and industrial laboratories.

Physical Properties

Melting Point: 250 °C (dec.)(lit.)

Boiling Point: 449.3 °C at 760 mmHg

Flash Point: 13 °C

Density: 0.862

Solubility: 0.1-0.5 g/100 mL at 20 ºC

Storage: 2-8°C

Analytical Data

Appearance: White to pale yellow crystalline powder