Raubasine (Ajmalicine), with CAS number 483-04-5, is a monoterpenoid indole alkaloid primarily isolated from the roots of *Rauvolfia serpentina* and other plants in the *Rauvolfia* genus. It is a stereoisomer of tetrahydroalstonine and shares structural similarities with other yohimbine-type alkaloids. Its primary and most significant application is in the pharmaceutical field, specifically as an active pharmaceutical ingredient (API) for cardiovascular and cerebrovascular disorders. Raubasine acts as a peripheral α1-adrenergic receptor antagonist, leading to vasodilation and improved blood flow. It is clinically used to treat conditions such as peripheral and cerebral vascular insufficiency, hypertension, and symptoms of vertigo and tinnitus associated with vascular origin. It is also investigated for its potential neuroprotective and anti-inflammatory properties. As a natural product, it serves as a valuable reference standard in phytochemical analysis and pharmacological research. Its isolation and study contribute to the understanding of plant-derived medicines and their mechanisms of action.