L-VALINE,N-[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]-,METHYLESTER,MONOHYDROCHLORIDE, CAS No. 482577-59-3

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482577-59-3

Catalog No. EBD16129

CAS 482577-59-3

Name L-VALINE,N-[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]-,METHYLESTER,MONOHYDROCHLORIDE

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Basic Information

Synonyms: N-[(2'-cyano[1,1'biphenyl]-4-yl)methyl]-methylesterL-valinemonohydrochloride Secondaryaminemethylestermonohydrochloride L-VALINE,N-[(2-CYANO[1,1-BIPHENYL]-4-YL)METHYL]-,METHYLESTER,MONOHYDROCHLORIDE N-(2-Cyanobiphenyl-4-Methyl)(L)ValineMethylEsterHCl L-Valine,N-[(2'-cyano[1,1'-biphenyl]-4-yl]methyl]-,methylester,hydrochloride CMVEH L-VALINE,N-[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]-,METHYLESTER,MONOHYDROCHLORIDE N-[(2'-Cyano[1,1'-biphenyl]-4-yl)methyl]-methylesterL-valine,monohydrochloride (S)-Methyl2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoate N-[(2'-Cyano[1,1

Molecular Formula: C20H23ClN2O2

Molecular Weight: 358.86

MDL Number: MFCD08460094

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Other Pharmaceutical Intermediates Medicinal Chemistry > APIs and Their Salts > Cardiovascular Drugs

Product Description:

N-[(2'-Cyanobiphenyl-4-yl)methyl]-L-valine methyl ester hydrochloride is a key chiral intermediate in the synthesis of Valsartan, a widely prescribed angiotensin II receptor blocker (ARB) used for the treatment of hypertension and heart failure. Its structure incorporates the critical (S)-valine ester moiety and the biphenyltetrazole precursor (masked as a nitrile), which are essential pharmacophores for binding to the AT1 receptor. This compound is specifically designed for the industrial-scale manufacturing of the active pharmaceutical ingredient (API). The process involves further chemical transformations, including tetrazole ring formation from the cyano group, to yield the final drug substance. Its production and quality control are critical steps in ensuring the efficacy and safety of the final cardiovascular medication. As a dedicated synthetic building block for a major pharmaceutical, it is not a general-purpose reagent. Its primary value lies in its role within a well-defined synthetic route to a blockbuster drug, making it a significant intermediate in the pharmaceutical supply chain.

Physical Properties

Melting Point: 186 °C