2,4,6-Trimethylbenzoicacid, CAS No. 480-63-7

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480-63-7

Catalog No. EBD26642

CAS 480-63-7

Name 2,4,6-Trimethylbenzoicacid

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Basic Information

Synonyms: Mesitoicacid Mesitylene-2-carboxylicacid 2,4,6-TrimethylBenzoicAcid 2,4,6-trimethylbenzoate Mesitylenecarboxylicacid

Molecular Formula: C10H12O2

Molecular Weight: 164.2

MDL Number: MFCD00002481

Categories: Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters

Product Description:

2,4,6-Trimethylbenzoic acid, also known as mesitoic acid, is an aromatic carboxylic acid featuring a benzene ring substituted with three methyl groups at the 2, 4, and 6 positions. This structural motif imparts significant steric hindrance around the carboxyl group, making it a valuable building block in organic synthesis. It is commonly used as a synthetic intermediate for the preparation of sterically hindered esters, amides, and other derivatives. In the pharmaceutical industry, 2,4,6-trimethylbenzoic acid serves as a key intermediate in the synthesis of certain drug molecules and active pharmaceutical ingredients (APIs), particularly where the mesityl group is required for specific biological activity or metabolic stability. Its primary application, however, lies in organic chemistry as a hindered carboxylic acid building block for constructing complex molecules, including ligands for metal catalysts and precursors for functional materials.

Physical Properties

Melting Point: 152-155 °C(lit.)

Boiling Point: 296.6 °C at 760 mmHg

Flash Point: 138 °C

Density: 1.088 g/cm3

Solubility: soluble in ethanol and chloroform

Analytical Data

Appearance: white to almost white crystalline powder