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    478646-33-2

    Catalog No. EBD36

    CAS 478646-33-2

    Name (S)-Piperidin-3-yl-carbamic acid benzyl ester

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    Basic Information

    Synonyms: benzyl(3S)-piperidin-3-ylcarbamate Carbamicacid,N-[(3S)-3-piperidinyl]-,phenylmethylester (S)-3-N-Cbz-AMINO-PIPERIDINE benzylN-[(3S)-piperidin-3-yl]carbamate (S)-Piperidin-3-yl-carbamicacidbenzylester

    Molecular Formula: C13H18N2O2

    Molecular Weight: 234.29

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    (S)-Piperidin-3-yl-carbamic acid benzyl ester is a chiral piperidine derivative featuring a Cbz-protected amino group at the 3-position. This compound serves as a crucial chiral building block in pharmaceutical synthesis. Its primary application is as a key intermediate in the preparation of various active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system and other therapeutic areas. The (S)-configured stereocenter and the protected amine functionality make it a versatile precursor for constructing complex molecules. It is frequently employed in the synthesis of drug candidates where the piperidine scaffold is a core structural element. The Cbz (carboxybenzyl) protecting group can be selectively removed under mild hydrogenation conditions, allowing for further functionalization of the amine. As a high-value chiral intermediate, it is widely available from fine chemical suppliers for research and development purposes. Handling requires standard precautions for laboratory chemicals, and it should be stored in a cool, dry place.
    Physical Properties

    Boiling Point: 396.3 °C at 760 mmHg

    Flash Point: 193.5 °C

    Density: 1.13 g/cm3

    mg g kg ml l t