(S)-1-Boc-3-isopropylpiperazine, CAS No. 475272-54-9

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475272-54-9

Catalog No. EBD9394

CAS 475272-54-9

Name (S)-1-Boc-3-isopropylpiperazine

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Basic Information

Synonyms: 1-piperazinecarboxylicacid,3-(1-methylethyl)-,1,1-dimethylethylester,(3R)- 2-Methyl-2-propanyl(3R)-3-isopropyl-1-piperazinecarboxylate tert-butyl(3R)-3-(propan-2-yl)piperazine-1-carboxylate tert-Butyl(3R)-3-isopropylpiperazine-1-carboxylate tert-Butyl-(3R)-3-(propan-2-yl)piperazin-1-carboxylat tert-Butyl-(3R)-3-isopropylpiperazin-1-carboxylat tert-butyl(3R)-3-(1-methylethyl)piperazine-1-carboxylate 2-(2-(Trifluoromethyl)benzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (S)-1-Boc-3-isopropylpiperazine tert-Butyl(3R)-3-isopropylpiperazine-1

Molecular Formula: C12H24N2O2

Molecular Weight: 228.33

MDL Number: MFCD07772112

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

(S)-1-(tert-Butoxycarbonyl)-3-isopropylpiperazine is a chiral piperazine derivative featuring a tert-butoxycarbonyl (Boc) protecting group on one nitrogen and an isopropyl substituent on the carbon at the 3-position. This specific stereochemistry (S-configuration) is crucial for its application in asymmetric synthesis. This compound serves as a key chiral building block and intermediate in pharmaceutical research and development. Its primary application is in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. For instance, it is a critical intermediate in the production of certain antipsychotic drugs, where the chiral piperazine core is essential for binding to specific biological targets and achieving the desired therapeutic effect. As a Boc-protected secondary amine, it is a versatile synthon in organic chemistry, allowing for selective deprotection and further functionalization. Its use is predominantly confined to advanced research and small-scale synthesis for drug discovery rather than as a bulk commodity chemical.

Physical Properties

Boiling Point: 298.4 °C at 760 mmHg

Flash Point: 134.2 °C

Density: 0.98g/cm3