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    475-11-6

    Catalog No. EBD2206857

    CAS 475-11-6

    Name N-Methyl-L-proline

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    Basic Information

    Synonyms: N-Methyl-L-proline H-N-Me-Pro-OH

    Molecular Formula: C6H11NO2

    Molecular Weight: 129.16

    Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    N-Methyl-L-proline is a non-proteinogenic amino acid derivative, specifically a methylated analog of L-proline. It features a pyrrolidine ring structure with a secondary amine, where the nitrogen atom is substituted with a methyl group. This modification alters its physicochemical properties compared to proline, including its basicity and conformational flexibility. This compound serves as a key chiral building block and intermediate in pharmaceutical research and synthesis. It is notably utilized in the preparation of various bioactive molecules and drug candidates. For instance, it has been investigated as a component in the synthesis of matrix metalloproteinase (MMP) inhibitors and other therapeutic agents targeting specific enzymes or receptors. Beyond its primary role in medicinal chemistry, N-Methyl-L-proline is also employed as a ligand or auxiliary in asymmetric catalysis and as a precursor for more complex heterocyclic systems. Its chiral nature makes it valuable for constructing stereochemically defined molecules in both academic and industrial settings.
    Physical Properties

    Melting Point: 114-116 °C(lit.)

    Boiling Point: 227.1 °C at 760 mmHg

    Flash Point: 91.1 °C

    Density: 1.153 g/cm3

    Storage: −20°C

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