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    461-87-0

    Catalog No. EBD39836

    CAS 461-87-0

    Name 2-Fluoro-4-methylpyridine

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    Basic Information

    Synonyms: 2-fluoro-4-methylpyridine 2-Fluoro-4-picoline

    Molecular Formula: C6H6FN

    Molecular Weight: 111.12

    MDL Number: MFCD00041224

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

    Product Description:
    2-Fluoro-4-methylpyridine is a halogenated heterocyclic compound featuring a fluorine atom at the 2-position and a methyl group at the 4-position of the pyridine ring. It serves as a versatile and valuable building block in organic synthesis, particularly in the pharmaceutical industry. Its primary application is as a key intermediate in the synthesis of various active pharmaceutical ingredients (APIs) and agrochemicals. The fluorine atom and the methyl group offer sites for further functionalization, enabling the construction of complex molecules. It is notably used in the development of kinase inhibitors and other biologically active compounds where the pyridine core is a common pharmacophore. As a fluorinated pyridine derivative, it is a liquid at room temperature and should be handled with care under inert atmosphere due to its sensitivity. It is a fundamental reagent for introducing the 2-fluoro-4-methylpyridyl moiety into target molecules.
    Physical Properties

    Boiling Point: 160-161 °C(lit.)

    Flash Point: >230 °F

    Density: 1.078 g/mL at 25 °C(lit.)

    Refractivity: n20/D 1.472(lit.)

    Analytical Data

    Appearance: Clear colourless to light yellow liquid

    mg g kg ml l t