(1R,2R)-()-2-Amino-1-phenyl-1,3-propanediol, CAS No. 46032-98-8

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46032-98-8

Catalog No. EBD1837901

CAS 46032-98-8

Name (1R,2R)-()-2-Amino-1-phenyl-1,3-propanediol

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Basic Information

Synonyms: (1R,2R)-()-2-Amino-1-phenyl-1,3-propanediol (1S,2R)-2-amino-1-phenylpropane-1,3-diol (1R,2R)-1,3-dihydroxy-1-phenylpropan-2-aminium (1R,2R)-(-)-2-Amino-1-phenyl-1,3-propanediol (R(R*,R*))-2-Amino-1-phenylpropane-1,3-diol (2r,3s)-phenylserinol (1r,2s)-3-phenylserinol (2r,3r)-3-phenylserinol (1r,2r)-1-phenyl-2-amino-1,3-propanediol (1r,2r)-1-phenyl-2-aminopropane-1,3-diol [r(r*,r*)]-2-amino-1-phenylpropane-1,3-diol 1,3-propanediol,2-amino-1-phenyl-,[r-(r*,r*)]- (1R,2R)-2-Amino-1-phenyl-1,3-propanediol

Molecular Formula: C9H13NO2

Molecular Weight: 167.21

MDL Number: MFCD00069617

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

(1R,2R)-(-)-2-Amino-1-phenyl-1,3-propanediol is a chiral amino diol compound. It is a white to off-white crystalline powder. The molecule contains both amino and diol functional groups, making it a versatile chiral building block. This compound is primarily used as a key chiral intermediate in the pharmaceutical industry. Its most notable application is in the synthesis of chloramphenicol, a broad-spectrum antibiotic. The (1R,2R) stereochemistry is crucial for the biological activity of the final drug product. It also serves as a precursor for other pharmaceuticals and as a chiral ligand or auxiliary in asymmetric synthesis. As a bifunctional chiral synthon, it finds utility in organic chemistry for constructing complex molecules with defined stereocenters. It should be handled with care, using appropriate personal protective equipment, as it may cause skin and eye irritation.

Physical Properties

Melting Point: 112-118 °C(lit.)

Boiling Point: 360.6 °C at 760 mmHg

Flash Point: 171.9 °C

Density: 1.206 g/cm3

Refractivity: -26.5 ° (C=1, MeOH)

Safety Information

Packing Level: III

Hazard Category: 8

Transport Codes: 3259PSN1

Analytical Data

Appearance: light yellow powder