1-fluoro-4-methoxybenzene, CAS No. 459-60-9

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459-60-9

Catalog No. EBD1957991

CAS 459-60-9

Name 1-fluoro-4-methoxybenzene

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Basic Information

Synonyms: 4-METHOXYFLUOROBENZENE 1-fluoro-4-methoxy-benzen Anisole,p-fluoro- Benzene,1-fluoro-4-methoxy 4-Fluoroanisole

Molecular Formula: C7H7FO

Molecular Weight: 126.13

MDL Number: MFCD00000348

Categories: Synthetic Chemistry > Organic Building Blocks > Phenols and Ethers Synthetic Chemistry > Basic Synthetic Reagents > Other Basic Synthetic Reagents

Product Description:

4-Fluoroanisole is an organic compound with the molecular formula C7H7FO. It is a colorless to pale yellow liquid characterized by a benzene ring substituted with a fluorine atom and a methoxy group in the para position. This structure makes it a versatile aromatic ether building block. Its primary application is as a key intermediate in organic synthesis and pharmaceutical research. The presence of both an electron-donating methoxy group and an electron-withdrawing fluorine atom on the aromatic ring allows it to participate in various cross-coupling reactions, such as Suzuki and Buchwald-Hartwig couplings. It is commonly used to introduce the 4-fluoroanisole moiety into more complex molecules, particularly in the development of agrochemicals, liquid crystals, and active pharmaceutical ingredients (APIs). The compound is also utilized in material science, for instance, as a precursor in the synthesis of ligands and functional materials. It should be handled with care in a well-ventilated area, using appropriate personal protective equipment, as it is flammable and may cause skin and eye irritation.

Physical Properties

Melting Point: −45 °C(lit.)

Boiling Point: 157 °C(lit.)

Flash Point: 43 °C

Density: 1.114 g/mL at 25 °C(lit.)

Refractivity: n20/D 1.488(lit.)

Storage: Flammables area

Safety Information

Packing Level: III

Hazard Category: 3

Transport Codes: 3271

Analytical Data

Appearance: Colorless to light yellow liquid