4-Fluorobenzaldehyde, CAS No. 459-57-4

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459-57-4

Catalog No. EBD2223153

CAS 459-57-4

Name 4-Fluorobenzaldehyde

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Basic Information

Synonyms: 4-Fluorobenzaldehyde Fluorobenzaldehyde4 Fluorobenzaldehydecolorlessliq p-Fluorobenzaldehyde 4-fluoro-Benzaldehyde Benzaldehyde,p-fluoro PFAD Para-Fluorobenzaldehyde ParaFluoroBenzaldehyde

Molecular Formula: C7H5FO

Molecular Weight: 124.11

MDL Number: MFCD00003378

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Aldehydes and Ketones

Product Description:

4-Fluorobenzaldehyde is an aromatic aldehyde featuring a fluorine atom at the para position of the benzene ring. It has the molecular formula C7H5FO and a molecular weight of 124.11 g/mol. This compound is a colorless to pale yellow liquid with a characteristic almond-like odor and is widely used as a versatile building block in organic synthesis. Its primary application lies in the pharmaceutical industry as a key intermediate for the synthesis of various active pharmaceutical ingredients (APIs), including antifungal agents (e.g., fluconazole), antihistamines, and anti-inflammatory drugs. The fluorine atom enhances metabolic stability and lipophilicity, making it a valuable fragment in drug discovery. Additionally, it serves as a precursor for fluorinated polymers and agrochemicals. As a bifunctional molecule containing both an aldehyde group and a fluorine substituent, it readily undergoes nucleophilic addition, condensation, and cross-coupling reactions. It is also employed in the preparation of Schiff bases and fluorinated ligands for catalysis. Standard safety precautions should be taken as it is a flammable liquid and a skin irritant.

Physical Properties

Melting Point: −10 °C(lit.)

Boiling Point: 181 °C/758 mmHg(lit.)

Flash Point: 56 °C

Density: 1.157 g/mL at 25 °C(lit.)

Solubility: IMMISCIBLE

Refractivity: n20/D 1.521(lit.)

Safety Information

Packing Level: III

Hazard Category: 3

Transport Codes: 1989C

Analytical Data

Appearance: Clear colorless to yellow liquid